Variation and selection on codon usage bias across an entire subphylum
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چکیده
منابع مشابه
CodonO: codon usage bias analysis within and across genomes
UNLABELLED Synonymous codon usage biases are associated with various biological factors, such as gene expression level, gene length, gene translation initiation signal, protein amino acid composition, protein structure, tRNA abundance, mutation frequency and patterns, and GC compositions. Quantification of codon usage bias helps understand evolution of living organisms. A codon usage bias pipel...
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In a wide variety of organisms, synonymous codons are used with different frequencies, a phenomenon known as codon bias. Population genetic studies have shown that synonymous sites are under weak selection and that codon bias is maintained by a balance between selection, mutation, and genetic drift. It appears that the major cause for selection on codon bias is that certain preferred codons are...
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χ measure. In statistics, the χ statstic computes how different the distribution of values is from a uniform distribution. Let d = c1 . . . cN be a DNA string in nucleotide alphabet, and let L be the total number of codons in d that are not Methinine or Tryptophan (the number does include the stop codons though). Let a be a k-degenerate amino acid, and let La be the total number of codons codin...
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7. Karimpour, I., Cutler, M., Shih, D., Smith, J. and Kleene, K. (1992) DNA Cell Hiol. 11,693-699 8. Hill, K. E., Lloyd, R. S., Yang, J. G., Read, R. and Hurk, R. F. (1991) J. Biol. Chem. 266,10050-10053 9. Burk, R. F., Lawrence, R. A. and Lane, J. M. (1980) J. Clin. Invest. 65, 1024-1031 10. Rurk, R. F., Hill, K. E., Read, R. and Rellew, T. (1991) Am. J. Physiol. 261, E26-E30 11. Yang, J. G., ...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2019
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1008304